Dosage and Administration
Demeclocycline hydrochloride is administered orally.
Because food and/or milk reduce GI absorption of demeclocycline hydrochloride, the drug should be given 1 hour before or 2 hours after meals and/or milk.
To reduce the risk of esophageal irritation and ulceration, demeclocycline hydrochloride tablets should be administered with adequate amounts of fluid and probably should not be given at bedtime or to patients with esophageal obstruction or compression.
General Adult Dosage
The usual adult dosage of demeclocycline hydrochloride is 600 mg daily administered in 2 or 4 divided doses.
General Pediatric Dosage
The usual dosage of demeclocycline hydrochloride for children older than 8 years of age is 7-13 mg/kg daily (up to 600 mg daily) given in 2 or 4 divided doses.
The manufacturers state that uncomplicated gonorrhea in adults may be treated with an initial 600-mg dose of demeclocycline hydrochloride, followed by 300 mg every 12 hours for 4 days for a total of 3 g.
Tetracyclines are not included in current US Centers for Disease Control and Prevention (CDC) guidelines for the treatment of gonorrhea and doxycycline is the preferred tetracycline for presumptive treatment of coexisting chlamydial infections in patients with gonorrhea.
Syndrome of Inappropriate Antidiuretic Hormone Secretion
In the treatment of the chronic form of the syndrome of inappropriate antidiuretic hormone secretion (SIADH), a demeclocycline hydrochloride dosage of 600 mg to 1.2 g daily given in 3 or 4 divided doses has been effective in inhibiting the action of ADH in a dose-dependent manner. Diuresis usually occurs within 5 days after initiation of therapy and reverses within 2-6 days after discontinuation of the drug.
Dosage in Renal and Hepatic Impairment
If demeclocycline hydrochloride is used in patients with impaired renal function, doses and/or frequency of administration must be modified in response to the degree of renal impairment.
If demeclocycline hydrochloride is used in patients with impaired hepatic function, some manufacturers state that doses and/or frequency of administration must be modified in response to the degree of hepatic impairment.