Dicyclomine hydrochloride is used in the treatment of functional disturbances of GI motility such as irritable bowel syndrome. As with other antispasmodics, dicyclomine has limited efficacy in the treatment of these disorders and should be used only if other measures (e.g., diet, sedation, counseling, amelioration of environmental factors) have been of little or no benefit. Although dicyclomine has also been used in combination with phenobarbital in the treatment of irritable bowel syndrome, attempts to substantiate claims of efficacy for fixed combinations that include an antispasmodic and phenobarbital have generally failed and these combinations are generally considered as lacking substantial evidence of efficacy in the treatment of this condition.
Dicyclomine has been used alone and in combination with phenobarbital in the treatment of infant colic and acute enterocolitis, but the drug alone and the combination are generally considered as lacking substantial evidence of efficacy in the treatment of these conditions. Infant colic is considered a benign, self-limiting condition that tends to resolve spontaneously and not require medical treatment.