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fludrocortisone 0.1 mg tablet

In stock Manufacturer GLOBAL PHARM 00115703301
$0.45 / Tablet

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Mineralocorticoid Replacement

Fludrocortisone acetate is used for oral mineralocorticoid replacement therapy in patients with adrenocortical insufficiency or salt-losing forms of congenital adrenogenital syndrome after electrolyte balance has been restored. Because of its intense sodium-retaining activity, the drug is contraindicated in all conditions except those which require a high degree of mineralocorticoid activity.

In patients with adrenocortical insufficiency, hydrocortisone or cortisone (in conjunction with liberal salt intake) is usually the corticosteroid of choice for replacement therapy. Concomitant administration of a more potent mineralocorticoid (fludrocortisone) may be required in some patients. In salt-losing forms of congenital adrenogenital syndrome, cortisone or hydrocortisone should be administered in conjunction with liberal salt intake. If sodium loss and hypotension are not adequately controlled, fludrocortisone should also be given.

Postural Hypotension

Fludrocortisone acetate has been used with some success to increase systolic and diastolic blood pressure in patients with severe, chronic postural hypotension (e.g., secondary to autonomic dysfunction, levodopa therapy) that does not respond adequately to nondrug therapy.

Dosage and Administration

Fludrocortisone acetate is administered orally. Dosage depends on the severity of the disease and the response of the patient. Patients should be continually monitored for signs that indicate dosage adjustment is necessary, such as remissions or exacerbations of the disease and stress (surgery, infection, trauma).

Mineralocorticoid Replacement

Adrenocortical Insufficiency

For the treatment of adrenocortical insufficiency, the usual dosage of fludrocortisone acetate is 0.1 mg daily, although dosage may range from 0.1 mg 3 times weekly to 0.2 mg daily. If hypertension occurs, 0.05 mg of the drug is given daily. Cortisone (10-37.5 mg daily in divided doses) or hydrocortisone (10-30 mg daily in divided doses) is usually given orally concomitantly with fludrocortisone.

Salt-Losing Forms of Congenital Adrenogenital Syndrome

In the management of salt-losing forms of congenital adrenogenital syndrome, the usual dosage of fludrocortisone acetate is 0.1-0.2 mg daily.

Postural Hypotension

When fludrocortisone acetate was used to increase blood pressure in the management of diabetic patients with postural hypotension, 0.1-0.4 mg of the drug was given daily. In patients with postural hypotension secondary to levodopa therapy, 0.05-0.2 mg of fludrocortisone acetate has been given daily.

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