Precautions and Contraindications
Topical pramoxine preparations are for external use only. Contact of pramoxine topical preparations with the eyes and nose should be avoided.
Topical pramoxine preparations used for skin irritations should not be employed for vaginal, genital, or rectal itching. These preparations should not be applied to extensive areas of skin, open wounds, or damaged/blistered skin, and should not be used for prolonged periods. Pramoxine-containing lip ointment should not be used on deep or puncture wounds, animal bites, or serious burns.
Topical pramoxine preparations used for hemorrhoids or other anorectal disorders should not be inserted into the rectum using fingers or any mechanical device. The manufacturer of the aerosol foam preparation also warns against inserting any part of the aerosol container into the rectum. If rectal bleeding occurs during use of any of the topical pramoxine preparations, the drug should be discontinued and a clinician consulted.
Allergic reactions to pramoxine or any ingredients in the formulation may develop in certain individuals. If an allergic reaction occurs, the drug should be discontinued and a clinician consulted.
If erythema, irritation, swelling, pain, or other symptoms develop or worsen during therapy, pramoxine should be discontinued and a clinician consulted. Pramoxine also should be discontinued and a clinician consulted if pain and itching persist for more than 7 days, worsen, or resolve and occur again within a few days.