Prescription Required
In stock
Manufacturer
PERRIGO CO.
SKU
00574079001

methazolamide 25 mg tablet

Generic
$4.16 / tablet
+ -
1,000 tablets Available
Total Price:

Uses

Methazolamide is used only in the adjunctive treatment of open-angle (noncongestive, chronic simple) or secondary glaucoma and for short-term preoperative therapy in angle-closure (obstructive, narrow-angle) glaucoma when delay of surgery is desired in order to lower intraocular pressure.

Dosage and Administration

Administration

Methazolamide is administered orally.

Dosage

Dosage of methazolamide must be adjusted according to the patient's requirements and response. The usual adult dosage of methazolamide is 50-100 mg 2 or 3 times daily.

Cautions

Methazolamide shares the pharmacologic actions and toxic potentials of the carbonic anhydrase inhibitors, and the usual precautions of carbonic anhydrase inhibitor therapy should be observed. The manufacturers state that methazolamide is contraindicated in patients with severe or absolute glaucoma.

Pharmacokinetics

Absorption

Methazolamide is absorbed more slowly from the GI tract and disappears more slowly from the plasma than does acetazolamide.

Distribution

Methazolamide is distributed into plasma, erythrocytes, extracellular fluid, bile, the aqueous humor of the eye, and CSF. The drug crosses the placenta in unknown quantities. It is not known whether methazolamide is distributed into the milk of nursing women.

Elimination

Methazolamide is partially metabolized in the liver. About 20-30% of a dose is excreted in urine as substances with carbonic anhydrase inhibitor activity. The fate of the remainder of the dose has not been determined.

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