Metolazone shares the uses of the thiazide diuretics; however, there is some evidence that metolazone may be more effective than other thiazide-like diuretics in the management of edema in patients with impaired renal function.
Metolazone is used in the management of edema associated with heart failure and renal diseases (e.g., nephrotic syndrome, impaired renal function).
Metolazone has been used concomitantly with a loop diuretic to manage hypertension and/or induce diuresis in patients who did not respond to either diuretic alone (e.g., in those with advanced renal insufficiency), and metolazone alone may be effective in some patients who are unresponsive to a loop diuretic. For further information on the role of diuretics in antihypertensive therapy and information on overall principles and expert recommendations for treatment of hypertension,
Studies have not been performed to determine if metolazone is effective in the treatment of diabetes insipidus or renal tubular acidosis or in the prophylaxis of renal calculus formation associated with hypercalciuria.