Perphenazine is used for the symptomatic management of psychotic disorders (e.g., schizophrenia).
Drug therapy is integral to the management of acute psychotic episodes in patients with schizophrenia and generally is required for long-term stabilization to improve symptoms between episodes and to minimize the risk of recurrent acute episodes. Antipsychotic agents are the principal class of drugs used for the management of all phases of schizophrenia and generally are effective in all subtypes of the disorder and subgroups of patients. Patient response and tolerance to antipsychotic agents are variable, and patients who do not respond to or tolerate one drug may be successfully treated with an agent from a different class or with a different adverse effect profile. For additional information on the symptomatic management of schizophrenia, including treatment recommendations and results of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) research program,
Severe Nausea and Vomiting
Perphenazine is used for the control of severe nausea and vomiting in adults. Safe use of perphenazine for the prevention and treatment of nausea and vomiting of pregnancy has not been established, and the manufacturers recommend that the drug be used during pregnancy only when the potential benefits justify the possible risks to the fetus.
Perphenazine has not been shown to be effective for the management of behavioral complications in patients with mental retardation.