Phenazopyridine is used for the symptomatic relief of pain, burning, urgency, frequency, and other discomforts resulting from irritation of the lower urinary tract mucosa caused by infection, trauma, surgery, endoscopic procedures, or the passage of sounds or catheters. The use of phenazopyridine for relief of symptoms should not delay definitive diagnosis and treatment of causative conditions. The drug is not a substitute for specific surgery or antimicrobial therapy. Phenazopyridine also may be used for self-medication for the symptomatic relief of minor pain, urgency, frequency, and burning on urination.
Combinations of phenazopyridine hydrochloride with sulfonamides are commercially available for the initial treatment of uncomplicated urinary tract infections caused by susceptible organisms when relief of symptoms of pain, burning, or urgency is needed during the first 2 days of therapy. There is a lack of evidence that combinations of phenazopyridine hydrochloride with sulfonamides provide greater benefit than a sulfonamide alone after 2 days, and treatment beyond 2 days should only be continued with a sulfonamide alone.