Uses
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Edema
Torsemide is used for the management of edema associated with heart failure or hepatic or renal disease. Most experts state that all patients with symptomatic heart failure who have evidence for, or a history of, fluid retention generally should receive diuretic therapy in conjunction with moderate sodium restriction, an agent to inhibit the renin-angiotensin-aldosterone (RAA) system (e.g., angiotensin-converting enzyme [ACE] inhibitor, angiotensin II receptor antagonist, angiotensin receptor-neprilysin inhibitor [ARNI]), a β-adrenergic blocking agent (β-blocker), and in selected patients, an aldosterone antagonist. For additional information on the use of loop diuretics in the management of edema associated with heart failure, see Heart Failure under Uses: Edema, in , , and 40:28.08.
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Hypertension
Torsemide also is used alone or in combination with other classes of antihypertensive agents for the management of hypertension. Because of established clinical benefits (e.g., reductions in overall mortality and in adverse cardiovascular, cerebrovascular, and renal outcomes), angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists, calcium-channel blockers, and thiazide diuretics generally are considered the preferred drugs for the initial management of hypertension in adults. However, loop diuretics (e.g., furosemide, bumetanide, torsemide) may be particularly useful in patients with renal impairment (as an alternative to thiazide diuretics) or heart failure (for management of fluid retention). For additional information on the use of loop diuretics in the management of hypertension, see Uses: Hypertension, in 40:28.08.